Nate/George

As it is a reuseable monster destruction card, it is incredibly powerful even after undergoing several nerfs.
The easiest ways to overcome it are with effect destruction, Ability Shield monsters, or Confusing Controls.
As Nate/George is able to destroy only one monster per turn, summoning multiple monsters simultaneously can be a way to overcome it.
Nate/George is often used in conjunction with card drawers such as Ivory Library, to reduce its drawback of not being able to draw new cards.
However, some have used this drawback as an advantage as it can prevent one from decking. Although, they are still vulnerable to card drawers such as Touch of Knowledge and of course effect destruction.
Milling cards through the ability can also be advantageous, for powering graveyard synergies and the like, though it does put you closer to decking.

Card History

Jul 30th, 2005: Card released in War of the Webcomics.
Mar 6th, 2006: Effect type changed to weapon from none.
Mar 20th, 2006: Cost changed to 7 from 6.
Dec 5th, 2006 : Card changed to destroy target monster and mill a card instead of destroying target monster.
Jan 4th, 2008: Speed changed to from .
Feb 7th, 2012: Speed changed to from . Details in forum post